Website Banner (long) (crimson).jpg

Publications

Metabolic Alterations and Vulnerabilities in Hepatocellular Carcinoma

Tenen DG, Chai L & Tan JL*. Metabolic alterations and vulnerabilities in hepatocellular carcinoma. Gastroenterology Report 9, 1-13 (2021). *Corresponding author. [Invited review article]

New High-throughput Screen Identifies Compounds That Reduce Viability Specifically In Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation

Tan JL*, Li F, Yeo JZ, Yong KJ, Bassal MA, Ng GH, Lee MY, Leong CY, Tan HK, Wu CS, Liu BH, Chan TH, Tan ZH, Chan YS, Wang S, Lim ZH, Toh TB, Hooi L, Low KN, Ma S, Kong NR, Stein AJ, Wu Y, Thangavelu MT, Suzuki A, Periyasamy G, Asara JM, Dan YY, Bonney GK, Chow EK, Lu G, Ng HH, Kanagasundaram Y, Ng SB, Tam WL, Tenen DG & Chai L. New High-throughput Screen Identifies Compounds That Reduce Viability Specifically In Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation. Gastroenterology 157, 1615 (2019). *Co-corresponding author. [Editorial Highlight in Gastroenterology]

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma

Tan JL, Fogley RD, Flynn RA, Ablain J, Yang S, Saint-André V, Fan ZP, Do BT, Laga AC, Fujinaga K, Santoriello C, Greer CB, Kim YJ, Clohessy JG, Bothmer A, Pandell N, Avagyan S, Brogie JE, van Rooijen E, Hagedorn EJ, Shyh-Chang N, White RM, Price DH, Pandolfi PP, Peterlin BM, Zhou Y, Kim TH, Asara JM, Chang HY, Young RA & Zon LI. Stress from nucleotide depletion activates the transcriptional regulator HEXIM1 to suppress melanoma. Mol. Cell 62, 34-46 (2016). [Highlighted in News and Views in Pigment Cell & Melanoma Research]

Monitoring Structural Modulation of Redox-Sensitive Proteins in Cells with MS-CETSA

Sun W, Dai L, Yu H, Li F, Tan JL, Tenen DG, Lim YT, Chen MW, Sobota R, Prabhu N & Nordlund P. Monitoring structural modulation of redox-sensitive proteins in cells with MS-CETSA. Redox Biology 24, 101168 (2019).

A Zebrafish Melanoma Model Reveals Emergence of Neural Crest Identity During Melanoma Initiation

Kaufman CK, Mosimann C, Fan ZP, Yang S, Thomas AJ, Ablain J, Tan JL, Fogley RD, van Rooijen E, Hagedorn EJ, Ciarlo C, White RM, Matos DA, Puller AC, Santoriello C, Liao EC, Young RA, Zon LI. A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science 351, 464 (2016). 

Chemical Screening in Zebrafish for Novel Biological and Therapeutic Discovery

Tan JL & Zon LI. Chemical screening in zebrafish for novel biological and therapeutic discovery. Methods Cell Biol. 105, 493-516 (2011).