JUSTIN TAN LAB
Publications
SOX2 reprograms the methionine cycle via RMST-conferred AHCY sequestration in cancer
Ishrat I†, Bhat ZI†, Guo Z, Ho HKY, Ma R, Tang Q, Liang J, Huang Y, Zhang L, Wong YH, Jabado N, Yin W*, Tan HK*, Tan JL*. SOX2 reprograms the methionine cycle via RMST-conferred AHCY sequestration in cancer. Under revision, preprint available. †Equal contribution. *Corresponding author.
Scalable detection of cellular protein-small molecule interactions via fluorescence anisotropy.
Tang Q†, Wei Y†, Ma RR†, Wei N, Zhou TZ, Ho HK, Bhat ZI, Ishrat I, Li X, Yam JWP, Wong YH, Wang Q, Tan JL*. Scalable detection of cellular protein-small molecule interactions via fluorescence anisotropy. Under review, preprint available. †Equal contribution. *Corresponding author.
High-throughput, amplification-free detection of endogenous gene expression perturbations via fluorescence anisotropy.
Wei N†, Bhat ZI†, Tang Q†, Huang Y, Wong YH, Tan JL*. High-throughput, amplification-free detection of endogenous gene expression perturbations via fluorescence anisotropy. Under review, preprint available. †Equal contribution. *Corresponding author.
Targeting transcription factors through an IMiD independent zinc finger domain
Liu BH, Liu M, Radhakrishnan S, Dai M-Y, Jaladanki CK, Gao C, Tang JP, Kumari K, Go ML, Vu KAL, Kwon J, Seo, H-S, Song, K, Tian X, Li F, Tan JL, Melkonian AV, Liu Z, Wulf, G, Arthanari H, Qi J, Dhe-Paganon S, Clohessy JG, Choong YK, Sivaraman J, Fan H, Tenen DG, Chai L. Targeting transcription factors through an IMiD independent zinc finger domain. EMBO Mol. Med. (2025).
New High-throughput Screen Identifies Compounds That Reduce Viability Specifically In Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation
Tan JL*, Li F, Yeo JZ, Yong KJ, Bassal MA, Ng GH, Lee MY, Leong CY, Tan HK, Wu CS, Liu BH, Chan TH, Tan ZH, Chan YS, Wang S, Lim ZH, Toh TB, Hooi L, Low KN, Ma S, Kong NR, Stein AJ, Wu Y, Thangavelu MT, Suzuki A, Periyasamy G, Asara JM, Dan YY, Bonney GK, Chow EK, Lu G, Ng HH, Kanagasundaram Y, Ng SB, Tam WL, Tenen DG & Chai L. New High-throughput Screen Identifies Compounds That Reduce Viability Specifically In Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation. Gastroenterology 157, 1615 (2019). *Co-corresponding author. [Editorial Highlight in Gastroenterology]
Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma
Tan JL, Fogley RD, Flynn RA, Ablain J, Yang S, Saint-André V, Fan ZP, Do BT, Laga AC, Fujinaga K, Santoriello C, Greer CB, Kim YJ, Clohessy JG, Bothmer A, Pandell N, Avagyan S, Brogie JE, van Rooijen E, Hagedorn EJ, Shyh-Chang N, White RM, Price DH, Pandolfi PP, Peterlin BM, Zhou Y, Kim TH, Asara JM, Chang HY, Young RA & Zon LI. Stress from nucleotide depletion activates the transcriptional regulator HEXIM1 to suppress melanoma. Mol. Cell 62, 34-46 (2016). [Highlighted in News and Views in Pigment Cell & Melanoma Research]
A Zebrafish Melanoma Model Reveals Emergence of Neural Crest Identity During Melanoma Initiation
Kaufman CK, Mosimann C, Fan ZP, Yang S, Thomas AJ, Ablain J, Tan JL, Fogley RD, van Rooijen E, Hagedorn EJ, Ciarlo C, White RM, Matos DA, Puller AC, Santoriello C, Liao EC, Young RA, Zon LI. A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science 351, 464 (2016).